SELECTED PUBLICATIONS (* Corresponding author)  

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1. Xudong Wang, Chris Neale, Soo-kyung Kim, William A. Goddard, Libin Ye*. Intermediate-state-trapped Mutants Pinpoint Sequential Activation process of G protein-coupled Receptor. Nature Communications, in press.

2. Jesper J. Madsen, Libin Ye, Thomas Frimurer, Ole Olsen. Mechanistic basis of GPCR activation explored by ensemble refinement of crystallographic structures. Protein Science, accepted.

3. Libin Ye*, Xudong Wang, Aidan McFarland, and Jesper J. Madsen. 19F NMR--A promising Tool for Dynamic Conformational Studies of  G Protein-coupled Receptors. Structure, 2022, in press. More

4. Xudong Wang, Nabila Busha, Jesper Madsen, Martin Muschol, Libin Ye*. An In-membrane NMR Spectroscopic Approach Probing Native Ligand-GPCR Interaction. International Journal of Biological Macromolecules. 2022,206:911-916. More

5. Sriram S.K.S. Narayanan, Xudong Wang, Jose Paul, Vladislav Paley, Zijian Weng, Libin Ye*, Ying Zhong*. Disinfection and Electrostatic Recovery of N95 Respirators by Corona Discharge for Safe Reuse. Environmental Sciences & Technology, 2021: 55(22);15351-15360. More

6. Dennis D. Fernandes, Chris Neale, Gregory-Neal W. Gomes, Yuchong Li, Aimen Malik, Adi Pandey,  Alex Orazietti, Xudong Wang, Libin Ye*, R. Scott Prosser*, and Claudiu C. Gradinaru*. Ligand Modulation of the Conformational Dynamics of the A2A Adenosine Receptor Revealed by Single-Molecule Fluorescence. Scientific Reports, 2021, 11(1):5910. More

7. Wenjie Zhao, Xudong Wang, Libin Ye*. Expression and Purification of Yeast-derived GPCR, Ga and Gbg Subunits for Structural and Dynamic Studies , Bio-protocol, 2021, 11 (4), DOI: 10.21769/BioProtoc.3919. More

8. Xudong Wang, Wenjie, Zhao, Sameer Al-Abdul-Wahid, Yiming Lu, Tao Cheng, Jesper Madsen, Libin Ye*. Tri-fluorinated Keto-Enol Tautomeric Switch in Probing Domain Rotation of a G Protein-Coupled Receptor. Bioconjugate Chemistry, 2021, 32(1):99-105. More

9. Xudong Wang, Aidan McFarland, Jesper J. Madsen, Eric Aalo, Libin Ye*.The  Potential of 19F NMR Application in GPCR Biased Drug Discovery. Trends in Pharmacological Sciences, 2021,42(1): 19-30. More

10. Guang-Qiang Yin, Sneha Kandapal, Chung-Hao Liu, Heng Wang, Shu-Ting Jiang, Tan Ji, Yu Yan, Sandra Khalife, Libin Ye, Bingqian Xu, Hai-Bo Yang, Mu-Ping Nieh, Xiaopeng Li*. Metallo-Helicoid with Double Rims: Polymerization Followed by Folding via Intramolecular Coordination. Angewandte Chemie International Edition, 2020, 59: 2-11. More

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Before joining USF

1. Libin Ye, Chris Neale, Adnan Sljoka, Dmitry Pichugin, Nobuyuki Tsuchimura, Sacha T. Larda, Eps van Ned, Regis Pomes, Angel E. Garcia, Roger Sunahara, Oliver P. Ernst, R. Scott Prosser. Bidirectional allosteric modulation of the A2A adenosine G protein-coupled receptor by physiological cations. Nature Communications, 2018, 9(1):1372. More

2. Libin Ye, Alexander P. Orazietti, Aditya Pandey, Scott Prosser. High-efficiency expression of yeast-derived G protein-coupled receptor and 19F labeling for dynamical studies. Methods in Molecular Biology (Book chapter), 2018, 1688: 407-421. More

3. Taehun Kim, Pedram Mehrabi, Zhong Ren, Adnan Sljoka, Christopher Ing, Alexandr Bezginov, Libin Ye, Regis Pomes, R. Scott Prosser, Emil F Pai. The role of dimer asymmetry and subunit dynamics in enzyme catalysis. Science, 2017,355(6322): DOI: 10.1126/science.aag2355. More  

4. Libin Ye, Ned Van Eps, Marco Zimmer, Oliver P. Ernst, R. Scott Prosser. Activation of A2A adenosine G protein-coupled receptor by conformational selection. Nature, 2016, 533: 265–268. More

5. Roberto Brea, Christian Cole, Brent Lyda, Libin Ye; Scott Prosser, Roger Sunahara, Neal Devaraj. In situ reconstitution of the adenosine A2A receptor in spontaneously formed synthetic liposomes. Journal of the American Chemical Society, 2017, 139(10): 3607-3610. More

6. Libin Ye, Suvrajit Maji, Piraveen Gopalasingam, Evgeniy Gorbunov, Sergey Tarasov, Oleg Epstein and Judith Klein-Seetharaman. Structure and dynamics of insulin receptor: implication for receptor activation and drug discovery. Drug Discovery Today, 2017, 22(7): 1092-1102. More

7. Libin Ye, Ned van Eps, Oliver P. Ernst, and Scott Prosser. Utilizing tagged paramagnetic shift reagents to monitor protein dynamics by NMR. BBA-Proteins and Proteomics, 2017, 1865 (11): 1555-1563. More

8. Scott Prosser, Libin Ye, Aditya Pandey, Alexander Oraietti. Activation processes in ligand-activated G protein-coupled receptors: A case study of the adenosine A2A receptor. Bioessays, 2017, DOI: 10.1002/bies.201700072. More

9. Libin Ye, Sacha T. Larda, Yi Feng Frank Li, Aashish Manglik, R. Scott Prosser. A comparison of chemistry shift sensitivity of trifluoromethyl tags: optimizing resolution in 19F NMR studies of proteins. Journal of Biomolecular NMR, 2015, 62(1): 97-103. More

10. Libin Ye*, Xiaolin Zheng, Hongjian Zheng. Effect of sypQ gene on poly-N-acetylglucose-amine biosynthesis in Vibrio parahaemolyticus and its role in infection process. Glycobiology, 2014, 24(4): 351-358. (*corresponding author)

11. Libin Ye, Xiaoyun Su, George Schmitz, Young Hwan Moon, Roderick I. Mackie, Isaac K. O. Cann. Molecular and biochemical analyses of the GH44 module from CbMan5B/Cel44A, a bifunctional enzyme from the hyperthermophilic bacterium Caldicellulosiruptor bescii. Applied and Environmental Microbiology, 2012：7048-7059.

12. Libin Ye*, Lu Xu, Jianrong Li. Preparation and anticoagulant activity of a fucosylated polysaccharide sulfate from a sea cucumber Acaudina molpadioidea. Carbohydrate Polymers, 2012, 87(3): 2052-2057. (*corresponding author)

13. Libin Ye*, Xiaolin Zheng, Jingsong Zhang*, Yingjie Pan. Immuno-regulatory activity and biochemical characterization of a proteoglycan complex, LZ-D-7, from Ganoderma lucidum fruiting bodies. Food Research International, 2011, 44(1): 367-372. (*corresponding author)

14. Libin Ye, Jingsong Zhang, Shuan Zhou, Sheng Wang, Di Wu, Yinjie Pan. Preparation of a sulfated protein-heteroglycan and inhibiting L1210 cell property. Carbohydrate Polymers, 2009, 77(2): 276-279.

15. Libin Ye, Jingsong Zhang, Yan Yang, Shuan Zhou, Yanfang Liu, Hui Chen, Yinjie Pan. Structural characterization of a heteropolysaccharide by NMR spectra. Food Chemistry, 2009, 112: 962-966.

16. Libin Ye, Jingsong Zhang, Kan Zhou, Yan Yang, Shuan Zhou, Wei Jia, Ruixia Hao, Yingjie Pan. Purification, NMR study and immuno-stimulating property of a galactofucan from the fruiting bodies of Ganoderma lucidum.Planta Medica，2008, 74: 1-5.

17. Libin Ye, Jingsong Zhang, XiJun Ye, Qinjiu Tang, Yanfang Liu, Chunyu Gong, Xiuju Du, Yingjie Pan. Structural elucidation of the polysaccharide moiety of a glycopeptide (GLPCW-II) from Ganoderma lucidum fruiting bodies. Carbohydrate Research, 2008, 343: 746-752.

18. Libin Ye, Jianrong Li, Jingsong Zhang, Yingjie Pan. NMR characterization for polysaccharide moiety of a glycopeptide. Fitoterapia. 2010, 81: 93-96.

19. Libin Ye, Jingsong Zhang, Yingjie Pan. Application of NMR techniques in structural analysis of polysaccharide from edible fungi. Acta Edulis Fungi, 2007, 14(4): 68-75.

20. Libin Ye, Xiaolin Zheng, Jingsong Zhang, Yan Yang, Yucheng Meng, Jianrong Li, Wei Chen, Yingjie Pan. Composition analysis and immunomodulatory capacity of peptidoglycan from Lingzhi or Reishi medicinal mushroom, Ganoderma lucidum (W. Curt.: Fr.) P. Karst. strain 119 (Aphyllophoromycetideae). Internal Journal of Medicinal Mushroom, 2010, 12(2): 157-165.

21. Christian Theilacker, Zhigniew Kaczyriski, Andrea Kropec, Irina Sava, Libin Ye, Anna Bychowska, Otto Holst, Johannes Huebner. Serodiversity of opsonic antibodies against Enterococcus faecalis-glycans of the cell wall revisited. PLoS One, 2011, 6(3): e17839. 

22. Yan Yang, Libin Ye, Jingsong Zhang, Yanfang Liu, Qinjiu Tang, Wei Jia. Structural analysis of a bioactive polysaccharide, PISP1, from the medicinal mushroom, Phellinus igniarius. Bioscience, Biotechnology, and Biochemistry, 2009, 73(1): 134-139. 

23. Xiuju Du, Jinsgon Zhang, Yan Yang, Libin Ye, Qinjiu Tang, Wei Jia, Yanfang Liu, Shuan Zhou, Ruixiang Hao, Chunyu Gong, Yingjie Pan. Structural elucidation and immuno-stimulating activity of an acidic heteropolysaccharide (TAPA1) from Tremella aurantialba. Carbohydrate Research, 2009, 344(5): 672-678.