Publications:

1. Aidan McFarland, Malissa Fenton, Jesper J. Madsen, Libin Ye*.  Unraveling a Receptor-Mediated Bioluminescence Signaling Pathway in Red Tide Algae. Journal of Molecular Biology, 2025, in press.

2. Maxine Bi, Xudong Wang, Jinan Wang, Jun Xu, Wenkai Sun, Victor Ayo Adediwura, Yinglong Miao*, Yifan Cheng*, and Libin Ye*. Structure and function of an intermediate GPCR-Gabg complex. Nature Communications, 2025, 16:1100.

3. 1Canjia Zhai, Ethan Cross Zulueta, Alexander Mariscal, Chengkai Xu, Yunpeng Cui, Xudong Wang, Huang Wu, Carson Doan, Lukasz Wojtas, Haixin Zhang, Jianfeng Cai, Libin Ye, Kun Wang, and Wenqi Liu. From Small Changes to Big Gains: Pyridinium-Based Tetralactam Macrocycle for Enhanced Sugar Recognition in Water. Chemical Sciences, 2024, 15: 19588-19598.

4. Heng Liu, Yunpeng Cui, Xue Zhao, Lulu Wei, Xudong Wang, Ning Shen, Timothy Odom, Xuming Li, William Lawless, Wayne Guida, Chuanhai Cao, Libin Ye, Jianfeng Cai*. Helical sulfonyl-γ-AApeptides modulating Aβ oligomerization and cytotoxicity by recognizing Aβ helix. PNAS, 2024, 121, 6, e2311733121.

5. Jesús Giraldo*, Jesper J. Madsen, Xudong Wang, Lei Wang, Cheng Zhang, Libin Ye*. A 19F-qNMR-guided mathematical model for G protein-coupled receptor signaling. Molecular Pharmacology, 2023, 105(1): 54-62.

6. Xudong Wang, Chris Neale, Soo-Kyung Kim, William A. Goddard, Libin Ye*. Intermediate-state-trapped mutants pinpoint sequential activation process of G protein-coupled receptor. Nature Communications, 2023, 14(1):1325

7. Sriram S. K S Krishnamoorthy, Zijian Weng, Andrew Tenjo, Marcelo Farfan, Parinitha Giridharan, Xudong Wang, Valerie Zapata, Xing Ma, Libin Ye, Ehsan Sheybani, Ying Zhong. Automated corona discharge (CD) for efficient and broad-spectrum surface and air sterilization. Journal of Materials Chemistry C, 2023, 11: 111834-11841.

8. Jesper J. Madsen, Libin Ye, Thomas Frimurer, Ole Olsen. Mechanistic basis of GPCR activation explored by ensemble refinement of crystallographic structures. Protein Science, 2022, e4456. 

9. Xudong Wang, Nabila Bushra, Martin Muschol, Jesper J Madsen, Libin Ye*. An in-membrane NMR spectroscopic approach probing native ligand-GPCR interaction. International Journal of Biological Macromolecules, 2022, 206:911-916.

10. Libin Ye*, Xudong Wang, Aidan McFarland, and Jesper J. Madsen. 19F NMR—A promising tool for dynamic conformational studies of G protein-coupled receptors. Structure, 2022, 30(10): 1372-1384 (Review).

11. Sriram S.K.S. Narayanan, Xudong Wang, Jose Paul, Vladislav Paley, Zijian Weng, Libin Ye*, Ying Zhong*. Disinfection and electrostatic recovery of N95 respirators by Corona Discharge for safe reuse. Environmental Sciences & Technology, 2021: doi.org/10.1021/acs.est.1c02649. 

12. Dennis D. Fernandes, Chris Neale, Gregory-Neal W. Gomes, Yuchong Li, Aimen Malik, Adi Pandey, Alex Orazietti, Xudong Wang, Libin Ye*, R. Scott Prosser*, and Claudiu C. Gradinaru*. Ligand modulation of the conformational dynamics of the A2A adenosine receptor revealed by single-molecule fluorescence. Scientific Reports, 2021, 11(1):5910. 

13. Wenjie Zhao, Xudong Wang, Libin Ye*. Expression and purification of yeast-derived GPCR, Ga and Gbg subunits for structural and dynamic studies. Bio-protocol, 2021,11(4):e3919

14. Xudong Wang, Wenjie Zhao, Sameer Al-Abdul-Wahid, Yiming Lu, Tao Cheng, Jesper Madsen, Libin Ye*. Tri-fluorinated keto-enol tautomeric switch in probing domain rotation of a G protein-coupled receptor. Bioconjugate Chemistry, 2021, 32(1): 99-105.

15. Xudong Wang, Aidan McFarland, Jesper J. Madsen, Eric Aalo, Libin Ye*. The potential of 19F NMR application in GPCR biased drug discovery. Trends in Pharmacological Sciences, 2021, 42(1):19-30. (Review) 

16. Guang-Qiang Yin, Sneha Kandapal, Chung-Hao Liu, Heng Wang, Shu-Ting Jiang, Tan Ji, Yu Yan, Sandra Khalife, Libin Ye, Bingqian Xu, Hai-Bo Yang, Mu-Ping Nieh, Xiaopeng Li*. Metallo-helicoid with double rims:polymerization followed by folding via intramolecular coordination. Angewandte Chemie International Edition, 2021, 60(3): 1281-1289. 

17. Libin Ye, Chris Neale, Adnan Sljoka, Dmitry Pichugin, Nobuyuki Tsuchimura, Sacha T. Larda, Eps van Ned, Regis Pomes, Angel E. Garcia, Roger Sunahara, Oliver P. Ernst, R. Scott Prosser. Bidirectional allosteric modulation of the A2A adenosine G protein-coupled receptor by physiological cations. Nature Communications, 2018, 9(1):1372 

18. Libin Ye, Alexander P. Orazietti, Aditya Pandey, Scott Prosser. High-efficiency expression of yeast-derived G protein-coupled receptor and 19F labeling for dynamical studies. Methods in Molecular Biology (Book chapter), 2018, 1688: 407-421.

19. Taehun Kim, Pedram Mehrabi, Zhong Ren, Adnan Sljoka, Christopher Ing, Alexandr Bezginov, Libin Ye, Regis Pomes, R. Scott Prosser, Emil F Pai. The role of dimer asymmetry and subunit dynamics in enzyme catalysis. Science, 2017,355(6322): DOI: 10.1126/science.aag2355 

20. Libin Ye, Ned Van Eps, Marco Zimmer, Oliver P. Ernst, R. Scott Prosser. Activation of A2A adenosine G protein-coupled receptor by conformational selection. Nature, 2016, 533: 265–268. (F1000Prime recommended) 

21. Roberto Brea, Christian Cole, Brent Lyda, Libin Ye, Scott Prosser, Roger Sunahara, Neal Devaraj. In situ reconstitution of the adenosine A2A receptor in spontaneously formed synthetic liposomes. Journal of the American Chemical Society, 2017, 139(10): 3607-3610. 

22. Libin Ye, Suvrajit Maji, Piraveen Gopalasingam, Evgeniy Gorbunov, Sergey Tarasov, Oleg Epstein and Judith Klein-Seetharaman. Structure and dynamics of insulin receptor: implication for receptor activation and drug discovery. Drug Discovery Today, 2017, 22(7): 1092-1102. 

23. Libin Ye, Hongjian Zheng, Zhong Zhang, Yan Yang. Preparative isolation of 5 antioxidant constituents from the medicinal mushroom Phellinus baumii (Agaricomycetes) by high-speed countercurrent chromatography and preparative high-performance liquid chromatography. International Journal of Medicinal Mushrooms, 2017, 19(4):319-326. 

24. Libin Ye, Ned van Eps, Oliver P. Ernst, and Scott Prosser. Utilizing tagged paramagnetic shift reagents to monitor protein dynamics by NMR. BBA-Proteins and Proteomics, 2017, 1865 (11): 1555-1563. 

25. Scott Prosser, Libin Ye, Aditya Pandey, Alexander Oraietti. Activation processes in ligand-activated G protein-coupled receptors: A case study of the adenosine A2A receptor. Bioessays, 2017, DOI: 10.1002/bies.201700072. 

26. Libin Ye, Sacha T. Larda, Yi Feng Frank Li, Aashish Manglik, R. Scott Prosser. A comparison of chemistry shift sensitivity of trifluoromethyl tags: optimizing resolution in 19F NMR studies of proteins. Journal of Biomolecular NMR, 2015, 62(1): 97-103. 

27. Libin Ye*, Xiaolin Zheng, Hongjian Zheng. Effect of sypQ gene on poly-N-acetylglucose-amine biosynthesis in Vibrio parahaemolyticus and its role in infection process. Glycobiology, 2014, 24(4): 351-358. 

28. Libin Ye, Xiaoyun Su, George Schmit, Young Hwan Moon, Roderick I. Mackie, Isaac K. O. Cann. Molecular and biochemical analyses of the GH44 module from CbMan5BCel44A, a bifunctional enzyme from the hyperthermophilic bacterium Caldicellulosiruptor bescii. Applied and Environmental Microbiology, 2012; 7048-7059

29. Libin Ye*, Lu Xu, Jianrong Li. Preparation and anticoagulant activity of a fucosylated polysaccharide sulfate from a sea cucumber Acaudina molpadioidea. Carbohydrate Polymers, 2012, 87(3): 2052-2057. 

30. Libin Ye*, Xiaolin Zheng, Jingsong Zhang*, Qingqiu Tang, Yan Yang, Xiangyang Wang, Jianrong Li, Yan Fang Liu, Yingjie Pan. Biochemical characterization of a proteoglycan complex from an edible mushroom from Ganoderma lucidum fruiting bodies and its immunoregulatory activity. Food Research International, 2011, 44(1): 367-372. 

31. Libin Ye, Jingsong Zhang, Shuan Zhou, Sheng Wang, Di Wu, Yinjie Pan. Preparation of a novel sulfated glycopeptide complex and inhibiting L1210 cell lines property in vitro. Carbohydrate Polymers, 2009, 77(2): 276-279. 

32. Libin Ye, Jingsong Zhang, Yan Yang, Shuan Zhou, Yanfang Liu, Qingjui Tang, XiuJu Du, Hui Chen, Yinjie Pan. Structural characterization of a heteropolysaccharide by NMR spectra. Food Chemistry, 2009, 112: 962-966. 

33. Libin Ye, Jingsong Zhang, Kan Zhou, Yan Yang, Shuan Zhou, Wei Jia, Ruixia Hao, Yingjie Pan. Purification, NMR study and immuno-stimulating property of a galactofucan from the fruiting bodies of Ganoderma lucidum. Planta Medica，2008, 74: 1-5. 

34. Libin Ye, Jingsong Zhang, XiJun Ye, Qinjiu Tang, Yanfang Liu, Chunyu Gong, Xiuju Du, Yingjie Pan. Structural elucidation of the polysaccharide moiety of a glycopeptide (GLPCW-II) from Ganoderma lucidum fruiting bodies. Carbohydrate Research, 2008, 343: 746-752. 

35. Libin Ye, Jianrong Li, Jingsong Zhang, Yingjie Pan. NMR characterization for polysaccharide moiety of a glycopeptide. Fitoterapia. 2010, 81: 93-96. 

36. Libin Ye, Jingsong Zhang, Yingjie Pan. Application of NMR techniques in structural analysis of polysaccharide from edible fungi. Acta Edulis Fungi, 2007, 14(4): 68-75.

37. Libin Ye, Xiaolin Zheng, Jingsong Zhang, Yan Yang, Yucheng Meng, Jianrong Li, Wei Chen, Yingjie Pan. Composition analysis and immunomodulatory capacity of peptidoglycan from Lingzhi or Reishi medicinal mushroom, Ganoderma lucidum (W. Curt.: Fr.) P. Karst. strain 119 (Aphyllophoromycetideae). International Journal of Medicinal Mushroom, 2010, 12(2): 157-165. 

38. Christian Theilacker, Zhigniew Kaczyriski, Andrea Kropec, Irina Sava, Libin Ye, Anna Bychowska, Otto Holst, Johannes Huebner. Serodiversity of opsonic antibodies against Enterococcus faecalis-glycans of the cell wall revisited. PLoS One, 2011, 6(3): e17839. 

39. Yan Yang, Libin Ye, Jingsong Zhang, Yanfang Liu, Qinjiu Tang, Wei Jia. Structural analysis of a bioactive polysaccharide, PISP1, from the medicinal mushroom, Phellinus igniarius. Bioscience, Biotechnology, and Biochemistry, 2009, 73(1): 134-139. 

40. Xiuju Du, Jinsgon Zhang, Yan Yang, Libin Ye, Qinjiu Tang, Wei Jia, Yanfang Liu, Shuan Zhou, Ruixiang Hao, Chunyu Gong, Yingjie Pan. Structural elucidation and immuno-stimulating activity of an acidic heteropolysaccharide (TAPA1) from Tremella aurantialba. Carbohydrate Research, 2009, 344(5): 672-678. 

 

Patents

1.  Libin Ye, Xudong Wang. A high-throughput NMR approach for in-membrane protein ligand screening. US17/677,249, 2022

2.  Ying Zhong, Libin Ye. Corona discharge-based sterilization. US17/210,184, 2021

3.  Aidan McFarland, Libin Ye. Living Light: A Complete GPCR Calcium Signaling Pathway Controls Bioluminescence in a Red Tide Algae. Provisional patent, 2023.