top of page
Home: Overview
Libin photo.jpg

Libin Ye, Ph.D. ​

Associate Professor


Department of Molecular Biosciences

University of South Florida

4202 E Fowler Ave, Tampa, FL 33620-5250

Office: (813)974-6007, BSF216

Lab: BSF258-264



Likined in.jpeg
google scholar.png

Research Interests:

GPCR Pharmacology, NMR, Conformational Transitions and Dynamics, Drug Discovery, Signal Transduction, Bioengineering, and Chemical Biology


Brief Experience:

Associate Professor          Department of Molecular Biosciences, University of South Florida, Tampa, FL, USA, 2024—

Affiliate Member                H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL,  USA, 2019—

Assistant Professor           Department of Molecular Biosciences, University of South Florida, Tampa, FL, USA, 20182024

Postdoctoral Fellow         Department of Chemistry and Department of Biochemistry, University of Toronto, ON, 

                                             Canada, 2013—2018 

Postdoctoral Fellow         Department of Structural Biology, University of Pittsburgh Medical Center, PA, USA, 2012—2013

Postdoctoral Fellow         Carl R. Woese Institute for Genomic Biology and Energy Biosciences Institute, UIUC, IL, USA, 2011—2012 

Ph.D.                                    Department of Microbiology, Nanjing Agricultural University, Nanjing, China,  2004—2008

Course Teaching:

1. Molecular Biology of the Gene (4000-level undergraduates and 6000-level graduates)

2. General Microbiology (3000-level undergraduates)

3. GPCR Drug Discovery (4000-level undergraduates and 6000-level graduates)


Consultant Faculty           Eli Lilly and Company, Indianapolis, IN, USA, 2023—

Advisor                               ASBMB chapter at University of South Florida, 2023—

Academic Memberships:

  1. CCSG (H. Lee Moffitt Cancer Center)

  2. American Association for The Advancement of Science (AAAS)

  3. Biophysical Society

  4. American Society for Biochemistry and Molecular Biology

Representative Publications:

  1. Maxine Bi, Xudong Wang, Jinan Wang, Jun Xu, Wenkai Sun, Victor Ayo Adediwura, Yinglong Miao*, Yifan Cheng*, and Libin Ye*. Structure and function of an intermediate GPCR-Gabg complex. BioRxiv: doi: 10.1101/2024.04.02.587841

  2. Xudong Wang, Chris Neale, Soo-Kyung Kim, William A. Goddard, Libin Ye*. Intermediate-state-trapped mutants pinpoint sequential activation process of G protein-coupled receptor. Nature Communications, 2023, 14(1):1325

  3. Xudong Wang, Aidan McFarland, Jesper J. Madsen, Eric Aalo, Libin Ye*. The potential of 19F NMR application in GPCR biased drug discovery. Trends in Pharmacological Sciences, 2021, 42(1):19-30. 

  4. Libin Ye, Chris Neale, Adnan Sljoka, Dmitry Pichugin, Nobuyuki Tsuchimura, Sacha T. Larda, Eps van Ned, Regis Pomes, Angel E. Garcia, Roger Sunahara, Oliver P. Ernst, R. Scott Prosser. Bidirectional allosteric modulation of the A2A adenosine G protein-coupled receptor by physiological cations. Nature Communications, 2018, 9(1):1372 

  5. Libin Ye, Ned Van Eps, Marco Zimmer, Oliver P. Ernst, R. Scott Prosser. Activation of A2A adenosine G protein-coupled receptor by conformational selection. Nature, 2016, 533: 265–268. (F1000Prime recommended) 

bottom of page