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Ye Lab@
Department of Molecular Bioscience
Conformation, Dynamics, and Signal Transduction of GPCR
1. GPCR and Diseases
We study a set of diseases related GPCRs to understand their activations, especially the biased signaling, using a combinational toolkit, including NMR, BRET, cryo-EM, and MD simulation, for a better drug development.
Home: Overview
GPCRs constitute the largest transmembrane protein family with more than 800 members. They serve as gatekeepers, controlling transduction for a variety of physiological and pathogenic signals, and are involved in almost every aspect of physiological activities in our human body. It is therefore easy to imagine that any GPCR signaling dysfunction probably leads to a disease such as cancer, cardiac failure, neurological disease, Parkinson’s, obesity, etc. Although only 10% of GPCRs have been subjected to drug discovery, they are already targeted by nearly 35% of FDA-approved medications, indicating a continued tremendous potential in drug discovery.
2. GPCR Evolution, Ecosystem, and Public Health
We also study a set of dinoflagellate GPCRs related to the occurrence of red tide blooms. Our vision for this line of research is to unravel the role of G protein-coupled receptor (GPCR) in the bioluminescent signaling process that are relevant to ecosystem, public health, and evolution with an aim of modulating these receptors in the red tide blooms, improving coastal ecosystem, and understanding unicellular GPCR in the evolution.
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